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NF-B can repress p53 activity through upregulation of the p53 inhibitor MDM2 [73] Alternatively, the IB kinase (IKK), a major player in the canonical NF-B pathway, can induce post-translational modifications in the p53 protein, altering its stability [74] (Figure 4A)

Using older data (going back more than 20 years) yields a PED estimate that is substantially smaller than when the data are restricted to only the most recent handful of years

Furthermore, NNK has been demonstrated to play a role in liver and pancreas cancer development in rodents [32]

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