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The effectiveness of screening and interventions for drug use in adolescents The optimal screening interval for detecting unhealthy drug use The accuracy of screening tools for detecting nonmedical use of prescription drugs, including opioids Strategies to improve access to pharmacotherapy and psychosocial interventions for persons with various types of drug use disorders The harms that occur when the result of screening is punitive The benefits and harms of providing prophylactic prescriptions for naloxone rescue therapy to patients in whom opioid misuse or opioid use disorders are detected after primary care screening Several organizations have issued statements about screening for drug use by asking about drug use