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The 19 pathways were as follows: ABC transporters (sulfate, N-acetyl-D-glucosamine, and L-arginine), protein kinase G (cGMP)-protein kinase G (PKG) signaling pathway (adenosine monophosphate, guanosine monophosphate, and adenosine), caffeine metabolism (1-methylxanthine, 7-methylxanthine, theobromine, and caffeine), arginine biosynthesis (oxoglutaric acid, L-arginine, ornithine, and argininosuccinic acid), mammalian target of rapamycin (mTOR) signaling pathway (adenosine monophosphate, and L-arginine), purine metabolism (sulfate, guanosine monophosphate, and adenosine monophosphate), histidine metabolism (oxoglutaric acid, 3-methyl-L-histidine, and anserine), retrograde endocannabinoid signaling [PC (20:0/18:2 (9Z,12Z), PE (18:3 (9Z,12Z,15Z)/18:0), and PGH2], Parkinsons disease (adenosine monophosphate, rotenone, and adenosine), longevity regulating pathway (resveratrol, and adenosine monophosphate), olfactory transduction (guanosine monophosphate, and adenosine monophosphate), arachidonic acid metabolism (2,3-dinor-8-iso-PGF2alpha, 11-dehydro-thromboxane B2, and 6-ketoprostaglandin E1), taurine and hypotaurine metabolism (2-hydroxyethanesulfonate, taurine, and oxoglutaric acid), adenosine monophosphate (AMP)-activated protein kinase (AMPK) signaling pathway (beta-D-fructose 2,6-bisphosphate, adenosine monophosphate, and AICAR), morphine addiction (adenosine monophosphate and adenosine), arginine and proline metabolism (L-arginine, ornithine, and creatine), tyrosine metabolism [gentisic acid, 5-(L-alanin-3-yl)-2-hydroxy-cis,cis-muconate 6-semialdehyde, and vanillylmandelic acid], D-arginine and D-ornithine metabolism (L-arginine and ornithine), and choline metabolism in cancer [choline and PC (20:0/18:2 (9Z,12Z)]

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