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In terms of therapeutic target validation, although treatment strategies based on programmed cell death provide new research directions for COPD treatment, many potential therapeutic targets are still in the basic research stage, and their effectiveness and safety in preclinical studies have not been fully validated (304)

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Interaction between endoplasmic/sarcoplasmic reticulum stress (ER/SR stress), mitochondrial signaling and Ca 2+ regulation in airway smooth muscle (ASM)