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208: 550-556 [DOI] [PMC free article] [PubMed] [Google Scholar] 32).Bernhard D, Csordas A, Henderson B, Rossmann A, Kind M, Wick G: Cigarette smoke metal-catalyzed protein oxidation leads to vascular endothelial cell contraction by depolymerization of microtubules

In both clinical and non-clinical in vivo studies, one can assess the level of oxidative stress by measuring urinary biomarkers such as 8-epi-Prostaglandine F2 [44], malondialdehyde or 4-hydroxynonenal [41]

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According to the World Health Organization (WHO), nearly 9 million people die every year due to tobacco use, including 1.2 million from secondhand smoke