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Nicotine biosynthetic genes harbor more than twice the frequency of GCC and G-box elements in their 2 kb upstream region than do their ancestral copies (Figure 3b), consistent with the hypothesis that the accumulation of GCC and G-box elements in promoter regions contributed to the evolution of the coordinated transcriptional regulation required for high-flux nicotine biosynthesis

8/10 edit: it's coming together

Approximately 865,000 Marylanders use tobacco and electronic smoking devices, most of them starting before age 21

It follows the fortunes of characters living on the fictional Chatsworth Estate in Manchester, centering on the Gallagher and Maguire families

Different plastics and resins were used for pipes in the '60s, some of them made from the same heat-resistant materials developed for space flight