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Large clusters of puffs in relatively quick succession result in a near-bolus dose of nicotine, rapid rise in blood nicotine levels, and likely greater nicotine-related effects (positive reinforcement)
In vivo PK profile data of drugs, such as the vasodilators for treating IUGR (Sharp and Alfirevic, 2015), are very rare
When given a dose of cocaine, these mice had an additional 74% increase in FosB expression compared to mice treated with cocaine alone
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