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EAPC was calculated by fitting a linear regression model to the natural logarithm of the age-standardized rates against the calendar year, following the formula y = a + bx + E, where y represents the natural logarithm of the age-standardized rate, x represents the calendar year, E is the standard error, and b is the calculated EAPC
doi: 10.1212/WNL.0000000000009437
10.1093/toxsci/69.1.265 Toxicol
Additionally, nicotine speeds up metabolism, and without it your body may burn food more slowly, according to the National Library of Medicine
