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In real-life, reduction of the nicotine content in cigarettes forces smokers to smoke more in order to get the same amount of nicotine on which they are dependent [1, 27]

[DOI] [PubMed] [Google Scholar] [132].Cadet J, Ravanat JL, Martinez GR, Medeiros MH, Di Mascio P, Singlet oxygen oxidation of isolated and cellular DNA: product formation and mechanistic insights, Photochemistry and photobiology, 82 (2006) 12191225

[11] A decoction is taken for colds, and the plant is also made into cough syrup

Oxidation of dNTPs and their subsequent misincorporation into the DNA can be followed by erroneous replication of the oxidized nucleotides during translesion DNA synthesis, thereby giving rise to mutation [124, 133]

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