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The tobacco "powder" or snuff became known as "Santacroce powder" or "santa polvere," that is, "holy powder." Pope Pius IV tasked Cistercian monks with growing tobacco in the Lazio region in the 16th century, and other monastic communities started growing the crop in other regions in Italy

This means that cannabinoids may impact serotonin receptors, so mixing antidepressants (specifically SSRIs) with marijuana may result in some positive and/or negative side effects

This reduces the surface area of the lungs and, in turn, the amount of oxygen that reaches your bloodstream

So I feel it doesnt matter

Publisher | Google Scholor Gillison ML, Broutian T, Pickard RK, Tong ZY, Xiao W, Kahle L, et al