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A mode of action and human relevance framework also was applied, which is summarized in Supplementary Table 3 (available online)

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Subjects who smoked cigarettes of higher yield (102 per cent increase) had higher cotinine and CO levels, due to greater intake per cigarette

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For instance, in the sedimentary records of ancient lakes, archaeologists regularly find the remains of things like wood associated with human settlement, which can remain intact for thousands of years