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Kim and Shin 42 analyzed the tobacco-specific nitrosamines NNN, NNK, and NAT and total tobacco-specific nitrosamines in 105 refill fluids from 11 companies in the Korean market and found nearly a 3-order-of-magnitude variation in tobacco-specific nitrosamine concentrations, with total tobacco-specific nitrosamine concentration ranging from 330 to 8600 g/mL

Applied Animal Behaviour Science , 125 (34), 157162

They are highly polluting due to the manufacturing process and the fact they contain thousands of harmful chemicals which are released into the water.