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Description
Early reports supported that ENDS liquids consisting of nicotine salts increased plasma nicotine levels from 35 to 72% when compared to first-generation e-cigarettes containing freebase nicotine [29]

Messner, B., & Bernhard, D

Additionally, e-liquid without nicotine may also drive hemodynamic alterations, as increases in SBP and DBP post-consumption were also identified after the use of nicotine-free ENDS [24]

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With pre-filled refills and pods and rechargeable batteries, many of these smaller devices are "plug and play"
