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The longer the truth was withheld, the more people smoked unaware of the damage it was causing to their bodies

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What is already known on this topic About half of all persistent cigarette smokers are killed by their habita quarter while still in middle age (35-69 years) After a large increase in cigarette smoking by young people, the full effects on national mortality rates can take more than 50 years to mature British men born in the first few decades of the 20th century could be the first population in the world in which the full long term hazards of cigarette smoking, and the corresponding benefits of stopping, can be assessed directly What this study adds Among the particular generation of men born around 1920, cigarette smoking tripled the age specific mortality rates Among British men born 1900-1909, cigarette smoking approximately doubled the age specific mortality rates in both middle and old age Longevity has been improving rapidly for non-smokers, but not for men who continued smoking cigarettes Cessation at age 50 halved the hazard

In particular, smoking has been shown to increase the levels of pro-apoptotic factors such as BAX and decrease the levels of anti-apoptotic factors such as BCL-2 in lung cells [111]

June 24, 2005