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While not as directly linked as bronchiolitis obliterans, chronic exposure to diacetyl might contribute to the development or worsening of chronic obstructive pulmonary disease (COPD)

We made overarching recommendations for intervention types, rather than doses, lengths, or rankings, because the overview of reviews approach that we used limited our ability to make detailed recommendations for each intervention individually

The 4 nicotinic receptor promotes CD4+ T-cell proliferation and a helper T-cell immune response