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If flat leaves are simply placed on top of each other, then rolled up like a beach towel, the flow of air and combustion will channel only through the center of the cigar, leaving the exterior unburned

[13] An alkaline pH causes more nicotine to be absorbed, especially the free, unprotonated form, but is irritating to the mucosa

Anticoagulation: Unfractionated heparin (UFH), low-molecular-weight heparin (enoxaparin), bivalirudin, or fondaparinux during acute phase

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