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Next, we step-wisely removed potential pleiotropic SNPs from the above PRSs to obtain the valid-PRSs, again based on a pre-defined set of P -value thresholds for the exploratory GWAS (i.e., 0.05, 0.1, 0.2, 0.3, 0.4, and 0.5)

These data indicate that substantial inequalities exist in terms of sex, age and education level concerning the share of adults who are daily smokers of cigarettes, while there are also considerable differences between the EU Member States with respect to smoking habits

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