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The answer to this question is important for smokers who are discovering vaping and want to successfully transition from tobacco to a product considered less harmful to health

156 It has been proposed that oxidative stress can inactivate HDAC2 by means of nitration or carboxylation and that HDAC2 is phosphorylated, ubiquitinated, and degraded as a consequence of cigarette smoke exposure

By non-specifically activating cytokine-driven pathways of systemic inflammation, cigarette smoking may also play a role in lowering the threshold for SLE onset

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