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30 found that hyperglycemia can accelerate the aging-like changes of endothelial cells and tissues, leading to structural and functional damage, and p300 knock-down can correct these abnormalities and slow down the aging-like changes

Protein lysate was electrophoretically separated on SDS-PAGE gels (4561084, Bio-Rad, Hercules, CA) and transferred to PVDF membranes (88518, ThermoFisher Scientific)

It has been observed that acetylation of p53 increases via oxidative stress-induced activation of the miR-34a/SIRT1/p53 pathway, resulting in increased testicular cell apoptosis in a type 2 diabetic rat model (75)

This process results in formation of two major metabolites: a non-toxic 3-hydroxy-APAP and a highly reactive metabolite N-acetyl-p-benzoquinone-imine (NAPQI) (Hazai et al., 2002)

Additionally, p53 can activate apoptosis-related genes encoding death receptors like Fas (also known as APO1) and KILLER/DR5 (Death Receptor 5) [12,43]