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As for nephroprotection, an RCT on the use of febuxostat vs topiroxostat show none improvement in urinary protein/creatinine ratio

In general, the SUA level linearly increased with the pack-years

doi: 10.1158/1055-9965.EPI-09-0959

Freeman's factory in Cardiff was announced in September 2007, with all work scheduled to move to the Ballymena factory by September 2009
