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cigarettes have tobacco a significant impact on the environment, not just health | Imperial News The End of Cigarettes Is
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P 75,000 women revealed a 13-fold higher incidence of lung cancer in individuals who currently smoke (HR 13.44, 95% CI 10.8016.75) and fourfold higher incidence in those who formerly smoked (HR 4.20, 95% CI 3.485.08) compared with those who had never smoked, but no increase was observed among never-smoking women with passive smoke exposure (HR 0.88, 95% CI 0.521.49) 257

This is consistent with reports that GSK3 promotes NRF2 degradation, whereas AKT-mediated phosphorylation of GSK3 inhibits this process, thereby stabilizing NRF2 and enhancing its nuclear localization 11,20,26,28

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