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Finally, one can also assess the immune cell responses to cMRTP aerosol exposure using cell lines or primary cells and compare them with those caused by cigarette smoke

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By combining these two principles, one can generally calculate (i) the dose at which a cMRTP aerosol has the same effect than cigarette smoke, (ii) their relative effects as a percentage, and (iii) the residual effect over cessation

If you know that the cartridge is pretty fresh and the battery recently charged then it's likely because you are puffing too much

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