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A meta-analysis of 22 studies (68,000 participants) showed that people with diabetes have an increased risk of LTBI, with an adjusted OR of approximately 1.21 (95% CI 1.141.29), while three cohort studies reported a pooled aRR of 1.26 (95% CI 0.712.23) ( 5.6 Autoimmune diseases Rheumatoid arthritis (RA) is one of the most common chronic autoimmune diseases in Europe and, particularly, North America, with a prevalence of 0.81.1%, compared with a global prevalence of 0.24% ( Systemic vasculitis also represents a significant autoimmune condition associated with increased TB risk