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Nitrosamines and other nitroso compounds in cigarette smoke are capable of covalently interacting with DNA, which alters the normal biological function of DNA and eventually induces carcinogenesis in the GI tract and in urinary bladder (81,82)

Things get more convoluted for him from there on out
Proper storage is essential to maintain their freshness and flavour

About 20 percent of the general adult population smokes
