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Review of toluene action: Clinical evidence, animal studies and molecular targets

In lung cancer, wtp53 inhibits cystine uptake by suppressing expression of SLC7A11, leading to reduced activity of GPX4 and cellular antioxidant capacity, which causes the onset of ferroptosis [76]

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Epigenetic modulation of stem cells in neurodevelopment: the role of methylation and acetylation

Later work demonstrated that the combined absence of the p53 target genes encoding the pro-apoptotic BH3-only proteins PUMA and NOXA (and to a lesser extent loss of PUMA alone) rendered lymphoid cells as resistant to DNA damage-inducing agents as loss of p53 itself [8, 9, 22]