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[31] Nicotine-containing e-liquids are extracted from tobacco that may contain impurities

These include diseases such as cancer, chronic obstructive pulmonary disease (COPD), heart disease, birth defects, and other health problems relating to nearly every organ of the body

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PLoS ONE 13 (12), 115 (2018) Glantz, S.A., Bareham, D.W.: E-cigarettes: use, effects on smoking, risks, and policy implications

By critically reviewing the advantages and disadvantages of each herbal cigarette, the perspective of the best formulation that is likely to be safer for consumption is highlighted, along with needed additional research to be conducted for proof of safety of other less-explored cigarettes