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[DOI] [PubMed] [Google Scholar] Higgins 2003 Higgins JPT, Thompson SG, Deeks JJ, Altman DG

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Second-line pharmacologic therapies, which have proven efficacy in helping patients to quit but do not have an FDA indication for smoking cessation and have undesirable side effects compared to first-line agents, include clonidine (Catapres) and nortriptyline (Pamelor;Aventyl), both available by oral administration

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