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As nicotine is a psychoactive substance, adolescent tobacco use represents an important form of substance misuse, often co-occurring with other risk behaviours (19)

Once the opioids slow down the GABA neurons, dopamine floods the brains pleasure circuits, resulting in a wave of pleasure and pain relief

When to Seek Professional Help Persistent sleep disruption that lasts for more than a few weeks, especially when accompanied by low mood or anxiety, deserves professional attention

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Waziry R, Jawad M, Ballout RA, Al Akel M, Akl EA