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On the other hand, typical signs of underdosing are craving, irritability, anxiety, food craving with frequent snacks, insomnia and smoking despite NRT [19]

Furthermore, the trend toward cleaner and more sophisticated smokeless alternatives, such as tobacco-free nicotine pouches, is drawing in consumers seeking the nicotine sensation without actually consuming tobacco

Although the prevalence of cigarette smoking has declined, the prevalence of e-cigarette consumption has risen 4,5

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We demonstrate that cTEVp retains proteolytic activity comparable to that of the standard TEVp while exhibiting improved thermostability