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Under the revised definition, nicotine will consist of any form of the chemical nicotine, including any salt or complex, regardless of whether the chemical is naturally or synthetically derived, and includes nicotinic alkaloids and nicotine analogs. We note that while this expanded definition pulls synthetic nicotine and nicotine analog products into the state flavor ban, this new definition appears to be limited to the flavor ban and, therefore, would not apply to California tax regulations

Is vaping safer than smoking cigarettes

Akhtar S, Sheikh AA, Qureshi HU

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Nicotine exposure gives rise to differential gene expression of endothelial cells, growth of atherosclerotic plaques, and angiogenesis [111, 112]