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Some of these processes along with the underlying neurophysiological changes are shown diagrammatically in Figure 1

The given neurobiological explanation is that nicotine stimulates acetylcholine receptors on the cell bodies situated in the ventral tegmental area of the midbrain

Quitting smoking is so hard because of the complex interplay between physical addiction to nicotine and the psychological habits formed around tobacco use, as studied in an article by the Centers for Disease Control and Prevention titled Why Quitting Smoking Is Hard. Physically, nicotine creates dependence by altering brain chemistry, leading to withdrawal symptoms such as irritability, cravings, and anxiety when a person tries to quit
