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In contrast, differences in weight outcomes between smokers and nonsmokers were observed in a randomized trial of weight gain prevention (Jeffery, McGuire, & French, 2002), with smokers being twice as likely to report large weight losses (5% of body weight) despite the interventions emphasis on making small changes to prevent weight gain rather than to produce weight loss

That helps to avoid possible interactions between the medications

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3 Reznick et al

This study does not account for the duration an individual is exposed to a cancer-related risk factor