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It removes pathogens from the mucus layer through mucociliary clearance, establishes barriers through tight and adherent junctions, and activates and recruits immune cells in the submucosa through cytokine and chemokine production [26, 27]

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More studies are needed on whether these products will increase cardiovascular disease risk in those who use them, but these latest findings, the researchers said, lend support to ongoing efforts to regulate or ban flavorings in tobacco and nicotine products