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Along with inflammation, epithelial to mesenchymal transition have been reported in people who smoke and patients with COPD, which may be one of the shared mechanisms leading to lung cancer in these patients [87,88,89,90,91]

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In 2016, only one other state, California, raised its MSLA to 21, and in 2017, New Jersey followed suit, becoming the third state with Tobacco 21 legislation at the state level

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