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These statements suggest that the anti-estrogenic effect of smoking may not have as much importance as its other pleiotropic roles (immunomodulation, activation of redox-sensitive factors, and so forth) in the contribution to the development of ACPA + RA considering the estrogen dependence of the PAD enzyme

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doi: 10.18632/oncotarget.17745

Studies show that, when comparing drinkers to non-drinkers, there is an average relative increase of about 10% in cancer risk among those who consume alcohol

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