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In line with this, evidence from the MAM model shows (i) 5 but not 1-3-GABA A receptors are reduced in the subiculum and CA1 [88], (ii) overexpression of the 5, but not 1, subunit normalizes hippocampal hyperactivity [32], and (iii) an 5-GABA A PAM was able to normalize hippocampal hyperactivity [34] and attenuate VTA dopaminergic firing to a greater extent than the non-specific benzodiazepine midazolam [33]

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