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Whether this compositional shift translates to higher lung cancer risk remains unsettled: Conventional observational studies are inconsistent and rarely stratify by potency, but Mendelian randomization (MR) analyses suggest a possible causal signal for lung cancer (and specifically squamous histology) with genetic liability to cannabis use/use disorder (65,66)

The overall sales of e-cigarettes in the US experienced a growth of approximately 47% over this period

They can use certain tobacco molecules in isolation, and they can "reconstruct" tobacco by other means, and sometimes this works, sometimes it doesnt