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Figure 1 2.1 Crosstalk with epidermal barrier dysfunction Epidermal barrier dysfunction is a critical initiating factor in the pathogenesis of chronic pruritus in AD, and the mast cellneuron axis plays an active role not only in responding to external insults but also in perpetuating barrier disruption and impaired repair ( On one hand, barrier impairment enhances the skins susceptibility to environmental stimuli

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Given away years earlier, it had been located by defense investigators

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The end of the music video concluded with the reality TV star smoldering into the camera and smiling as she hooked her thumb into the waistband of her pants