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Studies of nicotine gum use reported no effect on serum lipids, although a cross-sectional study of smokeless tobacco users found a higher prevalence of hypercholesterolemia

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Specifically, they found that men who smoke about one cigarette per day have a 48% (all studies) to 74% (studies controlling for confounders) higher risk of heart disease than men who never smoked, and a 25% higher risk of stroke

The US is comparatively lagging behind in this area, but at least there has been some advancement with the FDA recently approving the first nicotine-flavoured e-cigarette