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Keywords: animal models, cardiac function, cardiopulmonary physiology, clinical research, e-cigarette, inflammation, lung function, nicotine, vaping Graphical Abstract Abstract figure legend Data across both human and animal studies demonstrate that daily inhalation of e-cigarette or vaping device aerosols on a chronic basis will cause significant cardiopulmonary disease

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A review of 65 clinical studies in 2020 found some participants who switched from cigarettes to e-cigarettes reported bleeding in their gums

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