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Meanwhile early studies in animals indicate that there may be some long-term effects of heated tobacco on cardiovascular health and the central nervous system, but these results are yet to be seen in humans

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[108] The latest generation of e-cigarettes, "pod products", such as Juul, have the highest nicotine content (59 mg/mL), in protonated salt, rather than the free-base nicotine form found in earlier generations, which makes it easier for less experienced users to inhale