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Acknowledgements We thank Dr Kyoji Okita for insightful comments and for his role in the preparation of the graphs contained in this manuscript

[18] The degree to which teens are using e-cigarettes in ways the manufacturers did not intend, such as increasing the nicotine delivery, is unknown, [107] as is the extent to which e-cigarette use may lead to addiction or substance dependence in young people

This measure would also bring spending on tobacco prevention and cessation closer to the CDCs recommended funding level of $442 million annually by allocating about $121 million in additional funds to CTCP and CDE, bringing total spending on state tobacco control programs to about $194 million

The difference in past-month cigarette smoking among those with versus without past-year major depressive episode significantly narrowed from 11.5% in 2006 to 6.6% in 2019

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