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While direct evidence linking these specific pouch effects to cardiovascular outcomes is limited in these studies, such cellular pathways (inflammation, oxidative stress) are recognized contributors to cardiovascular pathology, a link extensively discussed for other nicotine products like E-cigarettes (27)
The reason is to prevent any chance of accidental activation and a potential fire in the cargo hold, where it would go unnoticed

hernia: OR 1.40, 95% CI 1.231.59

Other nations are extremely strict on vaping products such as e-liquids and therefore research first hand
