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We assessed the effects of instrumental variables for genetically influenced body mass index (BMI, 1244 SNPs) (Pulit et al., 2019) [31], waist-to-hip ratio (WHR, 621 SNPs) (Pulit et al., 2019) [31], Depression (58 SNPs) (Meng et al., 2024) [34], Type 2 Diabetes (T2D, 401 SNPs) (Vujkovic et al., 2020) [32], coronary artery disease (CAD, 208 SNPs) (Van Der Harst and Verweij, 2018) [33], serum Calcium level (225 SNPs) (Sinnott-Armstrong et al., 2021) [35], serum Vitamin D level (98 SNPs) (Sinnott-Armstrong et al., 2021) [35], Testosterone level (95 SNPs) (Sinnott-Armstrong et al., 2021) [35], and bone mineral density (BMD, 896 SNPs) (Morris et al., 2019) [36] for blood trait effects