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Nicotines Risky Health Effects Outside of the well-established risks of tobacco use, a substantial body of research has also linked nicotine, including synthetic, to a wide variety of harmful health effects, such as: Increased risk of heart attack and cardiovascular disorders Resistance to chemotherapy and higher risk of multiple cancer types Elevated risk of respiratory, gastrointestinal and kidney disorders High blood pressure Decreased immune response Negative impacts on reproductive health Long-lasting, life-threatening addiction Short-term side effects include: Irritation in the mouth and throat Abdominal pain and nausea Vomiting and diarrhea Increased blood pressure and heart rate Early symptoms of nicotine addiction, such as cravings, restlessness and insomnia Side Effects on Developing Brains Nicotine use also damages the human brain especially ones that are still developing

So then for 14 years they didn't play together

Pharmaceuticals have marketed products for years off-label

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