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These included unassisted quitting, nicotine replacement therapy (patches, gum, lozenges, inhalers, or sprays), prescription medications such as varenicline and bupropion, counseling with healthcare clinicians, referral to cessation specialists, telephone quitlines, smartphone apps, text messaging programs, web-based interventions, group cessation programs, family or peer support, behavioral therapy, motivational interviewing, workplace or organizational programs, point-of-sale educational aids, incentive-based interventions, and smokefree policy support frameworks.Willingness to use four or more evidence-based cessation methods was defined as the primary outcome variable, labeled High Healthcare Engagement. Four or more evidence-based cessation methods were used as the threshold to define High Healthcare Engagement because using multiple cessation strategies is strongly associated with higher quit success and sustained behavior change

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Why Flavored vape products may be attractive: Green apple tobacco flavor elicits reward-related behavior, upregulates Nachrs on Vta dopamine neurons, and alters midbrain dopamine and Gaba neuron function

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