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Toxic chemicals in the tobacco, Constrict blood vessels Decrease oxygen to the heart Increase heart rate Increase blood clotting Increase systemic oxidative stress, Reduce nitric oxide (NO) bioavailability, It causes endothelial dysfunction

Supplementary Information Appendices Appendix 1 There are numerous types of SLT-products available globally which differ markedly in terms of their preparation, method of use and toxicity [6]

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Under the leadership of the state-funded anti-smoking pressure group Action on Smoking and Health (ASH), and aided by the fleeting fury of the tabloid press, the medical profession campaigned first for a ban on sales to minors and then for the complete prohibition of oral snuff

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