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Chemical emissions In a reduced emission study published in the Journal of University of Occupational and Environmental Health, researchers at the Japan National Institute of Public Health concluded that The concentrations of nicotine in tobacco fillers and the mainstream smoke of IQOS were almost the same as those of conventional combustion cigarettes, while the concentration of TSNAs [tobacco-specific nitrosamines] was one fifth and CO [carbon monoxide] was one hundredth of those of conventional combustion cigarettes. Indoor air quality The MHLW and the Japan National Cancer Center conducted two studies to examine the impact of HTPs on indoor air quality

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By following approaches applied in previous research 12 , we considered low risk of bias if the total score was 1320, moderate risk of bias if the score was 712, and high risk of bias if the score was 6