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Nonetheless, assessing exposure to SHS at a population level is complicated because there is great variability in terms of the settings where people are exposed, source of exposure, the SHS concentration, the duration of exposure, the characteristics of the person concerned, and his/her history of exposure

Schindler AG, Soden ME, Zweifel LS, Clark JJ (2016) Reversal of Alcohol-Induced Dysregulation in Dopamine Network Dynamics May Rescue Maladaptive Decision-making

For instance, while some studies have participants abstain from smoking for 2 hours, other studies have participants refrain from smoking overnight or for up to 7 days.15 This may create discrepancies among samples because individuals with schizophrenia who can maintain abstinence for 7 days may represent a less neurocognitively vulnerable subgroup of patients, even more so than patients who are able to refrain from smoking for shorter periods, also hypothesized to be inherently less susceptible to neurocognitive deficits.6 Furthermore, several studies do not provide comprehensive information concerning confounders and use small samples, lack control groups, and employ cross-sectional designs without consideration of longitudinal outcomes

Potential effect of smoking on semen quality through DNA damage and the downregulation of Chk1 in sperm
