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Description
Monogenic IEI with excessive type 2 responses can be particularly difficult to distinguish from severe atopic disorders, which led to the proposal of the term primary atopic disorders (PAD) [501]

If Princes chart is accurate one would reasonably expect to find Hows tavern somewhere in the neighborhood of this junction
The eventual goal was to downplay the impact of smoking for younger consumers

doi: 10.1002/ijc.2910440410
Ive included links to some of these papers here
